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KMID : 0363420180320030016
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Journal of Korean Oriental Pediatrics
2018 Volume.32 No. 3 p.16 ~ p.25
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The Anti-Inflammatory Effect of Lonicera Japonica-Glycyrrhiza Uralensis Decoction on Ulcerative Colitis Induced by DSS in Mice
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Lee Yeon-Woo
Ahn Sang-Hyun
Kim Ho-Hyun
Kim Ki-Bong
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Abstract
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Objectives: The purpose of this study is to investigate the anti-inflammatory effect of Lonicera Japonica-Glycyrrhiza Uralensis decoction extracts (LGE) on ulcerative colitis in children and adolescents.
Methods: Colitis was induced by DSS (Dextran Sulfate Sodium) in C57BL/6 mice. The sample mice were divided into group of four. The mice in the control group were not inflammation-induced. The control group was composed of untreated ulcerative colitis elicited mice. The mice in the experimental group were administered with Pentasa and another experimental group mice were treated with LGE after colitis elicitation. The effects on ulcerative colitis were evaluated by the morphological changes of colonic mucosa, decrease in the effect of pro-inflammatory cytokines (TNF-α and NF-κB) and inflammatory cytokines (iNOS and COX-2) in the mucosa.
Results: LGE showed protective effects in DSS induced ulcerative colitis. LGE inhibited shortening of colon length and relieved the hemorrhagic erosion in colonic mucosa. LGE decreased pro-inflammatory cytokines (TNF-α and NF-κB) and inflammatory cytokines (iNOS and COX-2). According to the GC/MS analysis, N-methyl pyrrolidone (NMP) was identified.
Conclusions: The result shows the clinical efficacy of LGE and demonstrates possible treatment options for ulcerative colitis. Further investigations for biological activity and chemical analysis of LGE will be needed.
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KEYWORD
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Lonicera japonica, Glycyrrhiza uralensis, Ulcerative colitis, Anti-inflammation
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